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As an alternative, we all engineered a usually nonpathogenic E.?coli stress to generate the actual S.?aeruginosa-encoded AB killer Exotoxin A new (ToxA), which usually catalyzes your ADP ribosylation involving elongation element 2 (EF2) through individuals EF2 diphthamide #links# moiety, the posttranslationally changed histidine, and thus hindering proteins functionality ( Yates et?al., '06). ToxA

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