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, 2005; Stucki et?al., August 2005) (Figure?1). Placing involving mdc1 in the DSB generates a docking website for more DSB-repair proteins, such as the MRN-ATM complex (Chapman and Jackson, 08; Melander et?al., 08). Therefore, phosphorylation associated with H2AX simply by Cash machine advances outside the DSB, making ��H2AX domain names that reach regarding numerous kilobases across the chromatin

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